Urokinase Expression by Tumor Suppressor Protein p53
نویسندگان
چکیده
منابع مشابه
Regulation of the p53 tumor suppressor protein.
Mutations in the p53 tumor suppressor gene occur in about 50% of all human tumors, making it the most frequent target for genetic alterations in cancer (for recent reviews on p53 see Refs. 1–5). Such mutations probably facilitate carcinogenesis primarily through abrogating the tumor suppressor activities of the wild type p53 protein, although at least some forms of tumor-associated mutant p53 p...
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The p53 protein is finally swimming into focus. This became clear at the Sixth International p53 meeting, which was held in Israel in Tiberias on the shores of the Sea of Galilee in early November 1992. In recent years, the p53 protein has captured the imagination of a broad spectrum of biomedical researchers. Because of its potentially central role in human cancer, there is considerable impetu...
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The tumor suppressor p53 protein down-regulates in vitro the expression of several cellular and viral promoters. However, it is not clear whether this down-regulation reflects equivalent modulation of the activity of these promoters in vivo. Here, we propose a suitable system to assess the effect of p53 on gene expression in vivo: the pair of p53 antisense-transfected and parental HeLa cells. T...
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BACKGROUND Survivin is one of the inhibitors of the apoptosis gene family that has been implicated in both inhibition of apoptosis and mitosis regulation. p53 is one of the tumor suppressor genes; prevents tumor formation through cell cycle blocking and eliminates damaged cells via activation of apoptosis. OBJECTIVE To investigate the possible regulation of survivin by p53, we examined the ex...
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The focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. For this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (DCIS), was evaluated by immunohistochemical method. All specimens were microscopically classified into histologic types...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2008
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2007-0406oc